Clinical Significance
(Time-resolved Fluorescence lmmunochromatographic Assay)

NT-proBNP increases with age, women of the same age are higher than men, and the increase in age of people over 60 is even greater. The reference range of NT-proBNP in Europe is: <50 years old, male 84pg/ml, female 155pg/ml; >50 years old, male 194pg/ml, 222pg/ml. The analysis of the difference between age and gender has the following reasons: on the one hand, the myocardium of the elderly becomes stiff, and the increase of ventricular wall tension leads to an increase in its synthesis. Renal clearance of NT-proBNP is reduced, while BNP does not depend on renal clearance. Therefore, NT-proBNP reflects the comprehensive heart-kidney function.

Performance Parameter
Principle of Detection: Double antibody sandwich method
Type of Sample: Serum/Plasma/Whole Blood
Types of Anticoagulants: EDTA
Detection Range: 100~20000 pg/L
Reference range: <75 aged: 0-300pg/ml; ≥75 aged: 0-450pg/ml
Sample vol.: 30µL
Assay time: 15min
Storage: 2-30
Shelf life: 24 months
Precision within and between batches: Intra-assay CV ≤ 15%, Inter-assay CV ≤ 15%
Performance Parameter